Cardiology
Peer-reviewed articles on diseases of the heart and blood vessels.
This page collects peer-reviewed articles on diseases of the heart and blood vessels, from heart failure and ischaemic heart disease to vascular and cardiometabolic conditions. Most come from ASIDE Cardiovascular, with related articles from other ASIDE journals. It includes population-level mortality and trend studies, reviews, and clinical case reports. Every article is free to read under a CC BY 4.0 licence, and authors pay no fee to publish. Articles are listed newest first; follow a title to read the abstract and full text.
Articles from ASIDE Cardiovascular, ASIDE Case Reports, ASIDE Endocrinology, ASIDE Gastroenterology and ASIDE Internal Medicine, newest first.
Articles
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Trends and Sociodemographic Differences in Mortality Among U.S. Adults with Mitral Regurgitation as the Underlying Cause and Heart Failure as a Contributing Cause of Death, 1999–2024
Background: The coexistence of heart failure (HF) and mitral regurgitation (MR) contributes substantially to cardiovascular mortality in the United States. Methods: We analyzed CDC WONDER multiple-cause-of-death data (1999–2024) for U.S. adults with MR listed as the underlying…
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Trends in Mortality Involving Ischemic Heart Disease and Procedure-Related Conditions in U.S. Adults, 1999–2023
Background: Ischemic heart disease (IHD) is a leading cause of death in the United States, and death certificates may contain medical or surgical care-related codes among decedents with IHD. However, these codes do not establish procedural exposure, postoperative status, timing…
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Dysphagia Megalatriensis Secondary to Rheumatic Severe Mitral Regurgitation with Giant Left Atrium: A Case Report
Dysphagia megalatriensis is a rare condition caused by extensive left atrial dilatation, usually due to chronic rheumatic mitral valvular heart disease. It causes esophageal compression, which can be mistaken for primary esophageal conditions. A 45-year-old female patient with a…
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Acute Decompensated Heart Failure with Severe Left Ventricular Systolic Dysfunction of Undetermined Etiology in a 26-Year-Old Male: A Case Report
Heart failure with reduced ejection fraction HFrEF is rare in young adults but may develop when multiple uncontrolled cardiovascular risk factors are present. The diagnosis of an underlying cause of heart failure among younger patients is difficult due to multiple possible…
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Trends in Mortality Co-Reporting Heart Failure and Metabolic Syndrome–Related Conditions Among U.S. Adults Aged ≥25 Years, 1999–2023: A CDC WONDER Analysis
Background Heart failure frequently coexists with cardiometabolic conditions commonly associated with metabolic syndrome. Characterizing long-term mortality patterns involving these co-reported conditions may help identify populations with a disproportionate burden. Methods We…
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Ac-SDKP Maintains Coronary Microvascular Barrier Function and Prevents Radiation-induced Cardiac Injury
Background: Radiation-induced cardiomyopathy is a significant late complication in cancer survivors treated with thoracic radiation, with few preventive options. Early injury is characterized by coronary microvascular endothelial dysfunction and increased vascular permeability…
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Cardiogenic Shock and Sepsis-Related Mortality in the United States, 1999-2025: National Trends, Disparities, and Forecasts to 2040
Background: Cardiogenic shock (CS) complicated by sepsis is a life-threatening condition marked by circulatory collapse and systemic inflammation, with persistently high mortality despite critical care advances. National trends and disparities remain unclear. This study aimed to…
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Trends and Disparities of CVD Underlying-Cause Deaths with Pneumonia and Influenza Mentioned on the Death Certificate in the United States: A CDC WONDER Analysis.
Background: Pneumonia and influenza (P&I) may precipitate cardiovascular decompensation, yet long-term U.S. mortality patterns of P&I co-mention at death among cardiovascular disease (CVD) deaths are not well described across sociodemographic and geographic strata. Methods…
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Life-Threatening Pulmonary Embolism in a Patient with Suspected Antiphospholipid Syndrome and Severe Thrombocytopenia: A Case Report
Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by vascular thrombosis and obstetric complications in the presence of persistent antiphospholipid antibodies (aPL). Pulmonary embolism (PE), a frequent thrombotic manifestation of APS, can be…
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Hypoxemia After Inferior Atrial Septal Defect Repair Due to Iatrogenic Diversion of Inferior Vena Cava to Left Atrium: A Case Report
Iatrogenic diversion of the inferior vena cava (IVC) into the left atrium (LA) is a rare but serious complication of surgical atrial septal defect (ASD) repair, particularly in inferior or low-lying defects. When echocardiography is inconclusive, cross-sectional imaging can be…
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Cardiac Arrest and Cardiomyopathy Related Mortality in the United States, 1999-2025: Trends and Disparities
Background: Cardiac arrest and cardiomyopathy are major contributors to cardiovascular mortality and sudden death. However, long-term national mortality trends and demographic disparities remain unclear. This study aimed to evaluate U.S. mortality trends from 1999 to 2025 and…
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The Liver-Heart Axis: A Narrative Review of Clinical Implications of the MASLD Redefinition for Internists
Introduction: Metabolically-dysfunction-associated steatotic liver disease (MASLD) represents a paradigm shift emphasizing the metabolic underpinnings of hepatic steatosis and its systemic consequences. MASLD carries a substantial cardiovascular burden. This review examines the…
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Oral Sodium Bicarbonate as Adjunctive Therapy for Suspected Propafenone Cardiotoxicity in a Hemodynamically Stable Patient: A Case Report with Literature Review
We present the case of a 74-year-old male with a history of paroxysmal atrial fibrillation (PAF) and chronic kidney disease (CKD) who presented with fatigue. During hospitalization, telemetry captured an episode of hemodynamically stable wide-complex tachycardia consistent with…
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Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A Multisystemic Narrative Review of Cardiovascular and Oncological Implications
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) has surpassed viral hepatitis as the primary driver of chronic liver disease globally. While traditionally viewed through the lens of hepatic progression, its clinical trajectory is increasingly defined…
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Motion-Artifact ‘Pseudo–Type A Dissection’ on Ungated CTA in a Morbidly Obese Patient with Resolution on ECG-Gated CTA: A Case Report
We present a case of acute chest pain in a 48-year-old morbidly obese female with multiple comorbidities that raised suspicion for Acute Aortic Syndrome (AAS). The initial ungated PE-protocol CT angiogram (CTA) revealed a linear low-attenuation band in the ascending aorta…
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Mortality Trends and Disparities in Hypertensive Heart and Renal Disease: A 25-Year Analysis (1999–2023) Using the CDC WONDER Database
Background: Hypertensive heart and renal disease remain major contributors to mortality in the United States. Tracking long-term mortality patterns is essential for identifying high-risk populations and guiding public health strategies. Methods: We conducted a nationwide…
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Long-Term Mortality Trends in Atrial Fibrillation and Renal Disease in the United States, 1999–2023: A Retrospective Analysis
Background: The coexistence of atrial fibrillation (AF) and renal disease is a significant contributor to mortality and morbidity. However, comprehensive national mortality trends for AF among older adults with renal disease, including demographic and geographic variations…
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Infective Endocarditis with Severe Aortic Regurgitation Complicated by Type A Aortic Dissection in a Tricuspid Aortic Valve: A Case Report
Infective endocarditis (IE) is a severe infection of the endocardial surface, most commonly affecting cardiac valves. Aortic dissection (AD) is a rare but life-threatening complication of IE. We report a case of IE with severe aortic regurgitation (AR) complicated by Type A AD…
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Twenty-Five Years of Angina–Related Mortality in Elderly Adults Aged ≥ 65 Years: A Retrospective Cohort Study Using Real-World Data from the USA
Introduction: Angina is one of the ischemic heart diseases (IHD) that contributes to major cardiovascular complications up to death. We aim to assess angina-related mortality among adults aged ≥65 years in the U.S. Methods: Nationwide mortality records were obtained from the…
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A Pairwise and Network Meta-Analysis Comparing the Efficacy and Safety of Ribonucleic Acid Interference Therapeutics in the Management of Hypertension
Background: Small interfering RNA (siRNA) and antisense agents targeting angiotensinogen are emerging antihypertensives. We synthesized their efficacy and safety. Methods: We searched PubMed, Web of Science, Scopus, and CENTRAL through 25 Nov 2024. Eligible studies were…
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Trends in Mortality from Leukemia and Ischemic Heart Disease: A 22-Year Analysis in the U.S. (1999-2020)
Introduction: Leukemia and ischemic heart disease (IHD) are major U.S. mortality causes. This study analyzes national mortality trends from 1999 to 2020 to assess the impact of public health efforts in leukemia-associated IHD mortality rates. Methods: This retrospective study…
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Amiodarone-Induced Thyrotoxicosis Presenting as Congestive Heart Failure Exacerbation and Thyroid Storm: Role of Plasmapheresis in Management and Prevention of Complications
Amiodarone-induced thyrotoxicosis (AIT) is a subtype of thyrotoxicosis caused by the long-term administration of the antiarrhythmic drug amiodarone. It’s classified into type 1 AIT, which is defined as hypersecretion of the thyroid hormone, while type 2 AIT is destructive…
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Bridging the Gap between Evidence and Practice: Nationwide Retrospective Analysis of Lipid-Modifying Therapy Prescription Patterns in 5 Million Patients with Type 2 Diabetes Mellitus
Introduction: Type 2 diabetes mellitus (T2DM) is associated with dyslipidemia and significantly increased cardiovascular risk, making lipid-modifying therapy a crucial preventive intervention in these patients. Despite clear guidelines recommending statin therapy for both…
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Lifestyle Practices in Reducing Cardiovascular Diseases: A Prospective Cohort Study from Pakistan
Background: Cardiovascular diseases (CVD) remain the leading cause of global mortality, especially in individuals with comorbidities like type II diabetes and hypertension. While pharmacological therapies are vital, lifestyle interventions may offer additional benefits in…
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Management of Venous Thromboembolism in a Patient with Duplicated Inferior Vena Cava: A Case Report and Literature Review
Anatomic variations of the inferior vena cava (IVC) are rare, occurring in less than 3% of the population, yet they can pose significant clinical and procedural challenges. We report the case of a 68-year-old male with a contraindication to anticoagulation due to…
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Concurrent Diabetic Ketoacidosis and Acute Coronary Syndrome: A Systematic Review of Case Reports
Background: Diabetic ketoacidosis (DKA) and acute coronary syndrome (ACS) represent serious medical emergencies with a complex bidirectional relationship. The clinical presentations and outcomes of these conditions when they co-occur remain incompletely characterized in the…
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A Comprehensive Review of Fluid Resuscitation Techniques in Sepsis in Patients with Heart Failure
Introduction: Fluid management in sepsis patients with pre-existing heart failure presents a complex clinical challenge, as these patients require adequate resuscitation while avoiding fluid overload that could worsen cardiac function. This article aims to explore optimal fluid…
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The Impact of Idiopathic Intracranial Hypertension on Cardiovascular Disease Risk Among UK Women: An Obesity-Adjusted Analysis
Introduction: Idiopathic intracranial hypertension (IIH) is associated with increased cardiovascular disease (CVD) risk, but the relative contributions of obesity versus IIH-specific factors remain unclear. This study aims to disentangle the effects of obesity and IIH on stroke…
