Abstract
Iatrogenic diversion of the inferior vena cava (IVC) into the left atrium (LA) is a rare but serious complication of surgical atrial septal defect (ASD) repair, particularly in inferior or low-lying defects. When echocardiography is inconclusive, cross-sectional imaging can be critical for diagnosis.
A 17-year-old girl with a history of surgical closure of a low-lying ASD at 15 years of age presented with exertional dyspnea and mild oxygen desaturation of 90%-94%. Transthoracic echocardiography showed an intact atrial septal patch. Still, it could not clearly demonstrate the relationship of the inferior vena cava to the right atrium or assess the inferior margin of the repair. Contrast-enhanced CT angiography demonstrated direct drainage of the IVC into the LA with exclusion of the IVC orifice from the right atrium by the atrial septal patch, confirming iatrogenic diversion of the IVC. The patient was referred for surgical re-exploration and corrective re-repair. However, the details of the revision surgery are not available.
Iatrogenic diversion of the IVC should be suspected in postoperative ASD patients presenting with unexplained desaturation when echocardiography is inconclusive. CT angiography provides definitive delineation of caval drainage and patch anatomy, enabling accurate diagnosis. This case also underscores the importance of careful intraoperative identification of the inferior rim and confirmation of IVC drainage during repair of low-lying ASDs to prevent this complication.
References
1. Tayeh C, El Khoury M, Bitar F, Arabi M. Atrial septal defect closure complicated by anomalous inferior vena cava return to the left atrium: a case report of a 5-year-old child. Eur Heart J Case Rep. 2019: [PMID: 31449633, https://doi.org/10.1093/ehjcr/yty169]
2. Jain SA, Pinto R, Dalvi B. Iatrogenic diversion of IVC to left atrium after surgical closure of ASD. Ann Pediatr Cardiol. 2012: 72 [PMID: 22529607, https://doi.org/10.4103/0974-2069.93716]
3. Darwazah AK, Ibrahim BJ, Nairat M, Khdour I, Madi H. Iatrogenic diversion of inferior vena cava to the left atrium presented as recurrent foetal loss: a case report. Eur Heart J Case Rep. 2022: ytac348 [PMID: 36072424, https://doi.org/10.1093/ehjcr/ytac348]
4. Zhang H, Liu Q, Meng H, Xiong C. Iatrogenic diversion of inferior vena cava to the left atrium presented as persistent hypoxemia: Case series. Medicine (Baltimore). 2025: e41162 [PMID: 39833084, https://doi.org/10.1097/MD.0000000000041162]
5. Kim MS, Jang SY, Yang DH. Complications caused by iatrogenic right-to-left shunt after surgical closure of atrial septal defect: a case report. Eur Heart J Case Rep. 2021: ytab434 [PMID: 34917878, https://doi.org/10.1093/ehjcr/ytab434]
6. Fogel MA, Anwar S, Broberg C, Browne L, Chung T, Johnson T, Muthurangu V, Taylor M, Valsangiacomo-Buechel E, Wilhelm C. Society for Cardiovascular Magnetic Resonance/European Society of Cardiovascular Imaging/American Society of Echocardiography/Society for Pediatric Radiology/North American Society for Cardiovascular Imaging Guidelines for the use of cardiovascular magnetic resonance in pediatric congenital and acquired heart disease : Endorsed by The American Heart Association. J Cardiovasc Magn Reson. 2022: 37 [PMID: 35725473, https://doi.org/10.1186/s12968-022-00843-7]
7. Anderson RH, Baker EJ, Penny DJ, Redington AN, Rigby ML, Wernovsky G. Paediatric Cardiology. Philadelphia: Churchill Livingstone Elsevier; 2010. 683-690 p.
8. Hall JE. Guyton and Hall Textbook of Medical Physiology. Philadelphia: Elsevier; 2021. 239-245 p.

This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 2026 Amit Kumar Paliwal, RK Patel, Debraj Sen, Rachit Sharma, Saurabh Maheshwari

