Vol. 1 No. 3 (2025), Review Article
Vol. 1 No. 3 (2025)

Challenges and Infectious Complications in Living Donor Liver Transplantation in Egypt: A Comprehensive Review

Review Article
Published 2025-05-11
Ahmed Mohamed Ali Aref
Internal medicine department, Corewell Health William Beaumont University Hospital, Royal Oak, MI, USA. image/svg+xml
https://orcid.org/0009-0005-2924-4353
Ahmed H. Abdelwahed
Internal Medicine Department, University of Connecticut, CT, USA.  image/svg+xml
https://orcid.org/0000-0002-8165-836X
Abdelrahman Nassar
Internal medicine department, Faculty of medicine, Cairo university, Cairo, Egypt. image/svg+xml
https://orcid.org/0000-0002-5720-5272
Mohamed Elshennawy
Gastroenterology and Hepatology Department, Theodor Bilharz Research Institute, Giza, Egypt. image/svg+xml
https://orcid.org/0000-0001-8279-6812
Maryam Massoud
Department of Opthalmology, Faculty of Medicine, Cairo University, Cairo, Egypt. image/svg+xml
https://orcid.org/0009-0003-2411-175X
Nada Madkour
Internal Medicine Department, Alexandria University, Faculty of Medicine, Alexandria, Egypt. image/svg+xml
https://orcid.org/0000-0002-2036-4157
Esraa Awad
Internal Medicine Department, St. Joseph’s University Medical Center, Paterson, NJ, USA. image/svg+xml
https://orcid.org/0009-0006-6238-4144
Fatma Aljalawy
Department of Medical Physiology, Faculty of Medicine, Ain Shams University, Cairo, Egypt. image/svg+xml
https://orcid.org/0000-0002-0887-2984
Mohamed Akram Abdelwahab Hassan Khalil
Internal Medicine Department, Weiss Memorial Hospital, Chicago, IL, USA. image/svg+xml
https://orcid.org/0000-0003-1978-5744
Mohammed Y. Youssef
Gastroenterology and Hepatology Department, Mayo Clinic, Rochester, MN, USA. image/svg+xml
https://orcid.org/0000-0001-5631-9342
Omar Nassar
American Society for Inclusion, Diversity, and Equity in Healthcare, Lewes, DE, USA.
https://orcid.org/0000-0001-8492-7433
Mostafa Alfishawy
Infectious Diseases, Infectious Diseases Consultants, and Academic Researchers of Egypt (IDCARE), Cairo, Egypt.
https://orcid.org/0000-0002-9153-3237
ASIDE IM issue 3
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Keywords

Living donor liver transplantation
Infectious complications
Hepatitis C virus
Donor selection
Organ donation awareness

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How to Cite

1.
Aref AMA, Abdelwahed AH, Nassar A, et al. Challenges and Infectious Complications in Living Donor Liver Transplantation in Egypt: A Comprehensive Review. ASIDE Int Med. 2025;1(3):21-26. doi:10.71079/ASIDE.IM.05112553
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Abstract

Background: Living donor liver transplantation (LDLT) is a crucial therapeutic option for patients with end-stage liver disease in Egypt, where deceased donor grafts are scarce. This study aims to investigate the challenges and infectious complications associated with LDLT in Egypt.

Methods: A comprehensive review of relevant literature was conducted, focusing on factors affecting donor selection, the prevalence of infections in recipients, and the impact of healthcare providers' knowledge on organ donation. The study included data on complications affecting donors and recipients in the context of LDLT.

Results: The high prevalence of the hepatitis C virus and poverty in Egypt negatively impact the live donor pool. Lack of knowledge about liver donation, inadequate media coverage, and family pressure contribute to the low number of liver donors. Infectious complications play a significant role in the outcomes of LDLT, with bacterial infections being the most common. Donors also experience complications, with intraabdominal collections and pneumonia being the most frequent. Healthcare providers' knowledge and attitudes toward organ donation need improvement, and educational efforts should be tailored to the cultural and religious context.

Conclusion: Addressing the challenges in donor selection, raising public awareness about organ donation, and improving healthcare providers' knowledge are essential steps toward optimizing LDLT outcomes in Egypt. Moreover, it is crucial to monitor and manage infectious complications in both donors and recipients to ensure the success of the transplantation process.

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References

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