Neurology & Neuroscience
Peer-reviewed articles on disorders of the brain, spinal cord and nerves.
This page collects peer-reviewed articles on disorders of the brain, spinal cord and nerves, including stroke, neurovascular disease, neuro-ophthalmology and neurological complications of systemic illness. Most come from ASIDE Neurosciences, with related articles from ASIDE Internal Medicine and ASIDE Case Reports. It includes original research, systematic reviews and case reports. Every article is free to read under a CC BY 4.0 licence, and authors pay no fee to publish. Articles are listed newest first; follow a title to read the abstract and full text.
Articles from ASIDE Case Reports, ASIDE Gastroenterology, ASIDE Internal Medicine and ASIDE Oncology, newest first.
Articles
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Suspected Pembrolizumab-Associated Encephalitis Presenting as Altered Mental Status in an Elderly Patient with Cancer: A Case Report
Immune checkpoint inhibitors such as pembrolizumab are increasingly used in cancer therapy and are associated with rare but serious immune-related neurological adverse effects, including autoimmune encephalitis. An 83-year-old woman with stage IV non-Hodgkin lymphoma presented…
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Association of Irritable Bowel Syndrome with Dementia: A GRADE-Assessed Systematic Review and Meta-Analysis
Background: Numerous gastrointestinal (GI) diseases have been linked to an increased risk of dementia. Irritable bowel syndrome (IBS) is a prevalent GI disorder; however, existing studies investigating its association with dementia have reported mixed findings, and no prior…
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Psychological Burden in Behçet Disease: A Narrative Review Across Mucocutaneous, Articular, and Ocular Manifestations
Background: Behçet disease is a chronic, relapsing, multisystem inflammatory vasculitis in which mucocutaneous, articular, and ocular manifestations may coexist with substantial psychological burden. Methods: This narrative review synthesized English-language literature…
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Fatal Femoral Access-Site Pseudoaneurysm Following Multimodal Endovascular Stroke Reperfusion Therapy: A Case Report
Mechanical thrombectomy is an established treatment for acute ischemic stroke due to large-vessel occlusion, and transfemoral access is generally safe. However, access-site complications, though uncommon, can be severe. We report a fatal femoral access-site pseudoaneurysm…
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Adjunctive Remotely Supervised tDCS in Multiple Sclerosis: A GRADE-Assessed Meta-Analysis of Sham-Controlled Trials on Cognitive, Fatigue, Mobility, and Quality-of-Life Outcomes
Background: Multiple sclerosis (MS) is an immune-mediated disorder characterized by demyelination within the central nervous system, resulting in fatigue, pain, cognitive dysfunction, and motor impairment. Remotely supervised transcranial direct current stimulation (RS‑tDCS) is…
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HSV-2–Associated Mollaret’s Meningitis in a Patient with History of Prior Episodes: A Case Report
Mollaret meningitis is a rare, recurrent form of aseptic lymphocytic meningitis, most commonly caused by herpes simplex virus type 2 infection. The clinical presentation includes sudden, recurring attacks of headache, meningismus, and lymphocytic cerebrospinal fluid pleocytosis…
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Neuropsychiatric Decline in a Patient with Extensive Cerebral Metastases: An Overlooked Case of Antidepressant Discontinuation Syndrome
Acute behavioural changes in patients with newly discovered cerebral metastases are often attributed to disease progression, corticosteroid-induced psychosis, or oncological treatment-related toxicity. However, withdrawal of psychotropics such as Trazodone can cause similar…
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Posterior Reversible Encephalopathy Syndrome (PRES) Beyond Hypertension: Triggers, Pathophysiology, Management, and Outcomes
Introduction: Posterior reversible encephalopathy syndrome (PRES) is a neurovascular disorder characterized by vasogenic edema, most often affecting the parieto-occipital lobes. Although typically reversible, some patients develop lasting neurological sequelae such as cognitive…
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Stroke-Like Migraine Attacks After Radiation Therapy (SMART) Syndrome: A Case Report With Vertigo, Dysmetria, And Impaired Tandem Gait
SMART syndrome is a rare, delayed complication of brain radiation. The acronym SMART stands for stroke-like migraine attacks following radiation therapy. This case is one of the first to describe episodic vertigo, dysmetria, and impaired tandem gait following proton beam…
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Migraine Headache in Patients with Allergic Rhinitis: A Systematic Review and Meta-Analysis of Observational Studies
Background: Migraine is a condition characterized by recurrent episodes of unilateral headache. Allergic rhinitis (AR) is an IgE-mediated inflammatory condition of the nasal mucosa that is triggered by exposure to allergens. Migraine and AR may share underlying immunological…
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Rare Case of Disseminated Nocardiosis with Simultaneous Lung, Brain, and Spinal Cord Involvement in a Patient with Sarcoidosis
Nocardiosis is an uncommon opportunistic infection commonly affecting the lungs in immunocompromised individuals. We present an unusual case of disseminated nocardiosis involving the spinal cord and brain in a patient previously diagnosed with sarcoidosis and treated with…
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Dual association of autoimmune encephalitis with anti-NMDAR and anti-GAD65 antibodies: A Case Report with Literature Review
Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is the most common type of autoimmune encephalitis, whereas anti-glutamic acid decarboxylase 65 (antiGAD65) encephalitis is a rare autoimmune condition. The coexistence of these two conditions has been rarely reported…
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Human Readers versus AI-Based Systems in ASPECTS Scoring for Acute Ischemic Stroke: A Systematic Review and Meta-Analysis with Region-Specific Guidance
Introduction: The Alberta Stroke Program Early CT Score (ASPECTS) is widely used to evaluate early ischemic changes and guide thrombectomy decisions in acute stroke patients. However, significant interobserver variability in manual ASPECTS assessment presents a challenge. Recent…
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Efficacy and Safety of Optic Nerve Sheath Fenestration for Idiopathic Intracranial Hypertension: A Subgroup-Focused Systematic Review and Meta-Analysis
Introduction: Optic nerve sheath fenestration (ONSF) is an important surgical management option for patients with idiopathic intracranial hypertension (IIH) who have failed medical treatment. We conducted a systematic review and meta-analysis to evaluate the outcomes of ONSF and…
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Epidemiological Patterns, Treatment Response, and Metabolic Correlations of Idiopathic Intracranial Hypertension: A United States-Based Study From 1990 to 2024
Introduction: Idiopathic Intracranial Hypertension (IIH) presents an increasing health burden with changing demographic patterns. We studied nationwide trends in IIH epidemiology, treatment patterns, and associated outcomes using a large-scale database analysis within the United…
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Safety and Efficacy of Metformin for Idiopathic Intracranial Hypertension: A U.S.-Based Real-World Data Retrospective Multicenter Cohort Study
Introduction: Managing idiopathic intracranial hypertension (IIH) is challenging due to limited treatment options. This study evaluates metformin as a potential therapy for IIH, examining its impact on disease outcomes and safety. Methods: We performed a retrospective cohort…
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The Impact of Idiopathic Intracranial Hypertension on Cardiovascular Disease Risk Among UK Women: An Obesity-Adjusted Analysis
Introduction: Idiopathic intracranial hypertension (IIH) is associated with increased cardiovascular disease (CVD) risk, but the relative contributions of obesity versus IIH-specific factors remain unclear. This study aims to disentangle the effects of obesity and IIH on stroke…
