Abstract
Background: Venous thromboembolism (VTE) is a major cause of preventable morbidity and mortality in hospitalized patients. Evidence-based guidelines recommend systematic risk assessment and appropriate prophylaxis; however, adherence in routine clinical practice remains inconsistent.
Methods: A prospective, closed-loop clinical audit was conducted in the Department of Medicine at Khyber Teaching Hospital. Adherence to the National Institute for Health and Care Excellence guideline NG89 for VTE prevention was evaluated through a baseline point-prevalence audit of 237 adult medical inpatients. This was followed by a targeted educational intervention consisting of structured teaching sessions for interns and residents. A re-audit of 237 patients using identical inclusion criteria and data collection methods was conducted four weeks after the intervention.
Results: Baseline adherence to NICE NG89 recommendations was 54% (128/237). Following the educational intervention, adherence increased to 89% (211/237), representing an absolute improvement of 35 percentage points.
Conclusion: A focused educational intervention was associated with improved adherence to NICE NG89 VTE prophylaxis recommendations during the re-audit period. These findings suggest that structured educational strategies may improve guideline-based practice in resource-limited settings. However, the short follow-up period and pre–post design without a control group introduced the possibility of Hawthorne and secular effects, and longer-term sustainability was not assessed.
References
1. Alfehaid L, Alsuhebany N, Tawfik YMK, Alowais SA, Adnan S, Alfriah J, Alabdelmuhsin L, Alshehri AM, Alyami M. A comprehensive review of venous thromboembolism risk assessment models for hospitalized medical patients: comparative evidence, implementation challenges, and future directions. Frontiers in cardiovascular medicine. 2025: 1738139 [PMID: 41602342, https://doi.org/10.3389/fcvm.2025.1738139]
2. Narayan SW, Gad F, Chong J, Chen VM, Patanwala AE. Preventability of venous thromboembolism in hospitalised patients. Internal medicine journal. 2023: 577 [PMID: 34719859, https://doi.org/10.1111/imj.15600]
3. Yamamoto Y, Ogawa M, Okamoto T, Tsuboi M, Momosaki R. Acute-Phase Interventions and Clinical Implementation Challenges for Hospital-Associated Sarcopenia: A Narrative Review of a Multifaceted Approach to a Preventable Condition. Geriatrics & gerontology international. 2026: e70330 [PMID: 41566894, https://doi.org/10.1111/ggi.70330]
4. Nana M, Shute C, Williams R, Kokwaro F, Riddick K, Lane H. Multidisciplinary, patient-centred approach to improving compliance with venous thromboembolism (VTE) prophylaxis in a district general hospital. BMJ open quality. 2020: [PMID: 32718914, https://doi.org/10.1136/bmjoq-2019-000680]
5. Smythe MA, Koerber JM, Roberts A, Hoffman JL, Batke J. Hospital Acquired Venous Thromboembolism: A Preventability Assessment. Hospital pharmacy. 2024: 183 [PMID: 38450351, https://doi.org/10.1177/00185787231198164]
6. National Institute for H, Care E. Venous thromboembolism in over 16s: Reducing the risk of hospital-acquired deep vein thrombosis or pulmonary embolism | guidance | NICE: NICE; 2018. Available from: https://www.nice.org.uk/guidance/NG89.
7. Abdujawad AW, Al Raizah A, Al Saleh AS, Al Zahrani M, Hejazi A, Alotaibi S, Alkatheri Me, Alaskar A. A quality improvement project to optimize VTE prophylaxis in surgical patients. Blood. 2025: 2617 https://doi.org/10.1182/blood-2025-2617]
8. Abuzied Y, Deeb A, AlAnizy L, Al-Amer R, AlSheef M. Improving Venous Thromboembolism Prophylaxis Through Service Integration, Policy Enhancement, and Health Informatics. Global journal on quality and safety in healthcare. 2024: 22 [PMID: 38406656, https://doi.org/10.36401/JQSH-23-16]
9. Taha H, Govindraj E, Jaber F, Shehadeh G, Kelly B, Krishnan S, Hamed WK. Improving venous thromboembolism prophylaxis through critical thinking and health informatics. BMJ open quality. 2020: [PMID: 32487571, https://doi.org/10.1136/bmjoq-2019-000885]
10. Stokes T, Shaw EJ, Camosso-Stefinovic J, Imamura M, Kanguru L, Hussein J. Barriers and enablers to guideline implementation strategies to improve obstetric care practice in low- and middle-income countries: a systematic review of qualitative evidence. Implementation science : IS. 2016: 144 [PMID: 27770807, https://doi.org/10.1186/s13012-016-0508-1]
11. Odhus CO, Kapanga RR, Oele E. Barriers to and enablers of quality improvement in primary health care in low- and middle-income countries: A systematic review. PLOS global public health. 2024: e0002756 [PMID: 38236832, https://doi.org/10.1371/journal.pgph.0002756]
12. Ghobadi M, Behzadi A, Sabermahani A. The Outcomes, Barriers, and Facilitators of Implementing Clinical Practice Guidelines in Iran: A Comprehensive Review. Iranian journal of public health. 2024: 323 [PMID: 38894831, https://doi.org/10.18502/ijph.v53i2.14917]
13. Ogrinc G, Davies L, Goodman D, Batalden P, Davidoff F, Stevens D. SQUIRE 2.0 (Standards for QUality Improvement Reporting Excellence): revised publication guidelines from a detailed consensus process. BMJ quality & safety. 2016: 986 [PMID: 26369893, https://doi.org/10.1136/bmjqs-2015-004411]
14. Haroon MZ, Thaver IH. An assessment of existing surge capacity of tertiary healthcare system of Khyber Pakhtunkhwa Province of Pakistan using workload indicators for staffing need method. Human resources for health. 2022: 120 [PMID: 35090470, https://doi.org/10.1186/s12960-021-00663-3]

This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 2026 Dr. Fahad Naim, MBBS, FCPS, FRCP, Dr. Suleman Khan, MBBS, MD, Dr. Muhammad Saqib, MBBS, MD, Dr. Shabnam Shahjehan, MBBS, Dr. Farwa Aftab, MBBS, Dr. Muhammad Adeel Khan, MBBS, Dr. Nisar Ahmad, MBBS, Dr. Adam Saeed, MBBS, MD, Dr. Khaqan Ahmed, MBBS

