Probiotics: A Promising Ally in Burn Treatment

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  • Kholoud Al Jebawi Lebanese University, Faculty of Medical Sciences, Beirut, Lebanon. Lebanese University, Faculty of Science, Beirut, Lebanon. Medical Learning Skills Academy, Beirut, Lebanon.
      Competing Interests

      No competing interests 

    • Jobran Toami Lebanese University, Faculty of Medical Sciences, Beirut, Lebanon. Medical Learning Skills Academy, Beirut, Lebanon.
        Competing Interests

        No competing interests 

      • Adel Ayash Lebanese University, Faculty of Medical Sciences, Beirut, Lebanon. Lebanese University, Faculty of Science, Beirut, Lebanon. Medical Learning Skills Academy, Beirut, Lebanon. https://orcid.org/0009-0008-3532-284X
          Competing Interests

          No competing interests 

        • Razan Salha Lebanese University, Faculty of Medical Sciences, Beirut, Lebanon. Lebanese University, Faculty of Science, Beirut, Lebanon. Medical Learning Skills Academy, Beirut, Lebanon.
            Competing Interests

            No competing interests 

          • Mira Al Shoufy Lebanese University, Faculty of Medical Sciences, Beirut, Lebanon. Lebanese University, Faculty of Science, Beirut, Lebanon. Medical Learning Skills Academy, Beirut, Lebanon.
              Competing Interests

              No competing interests 

            • Jamil Nasrallah Lebanese University, Faculty of Medical Sciences, Beirut, Lebanon. Lebanese University, Faculty of Science, Beirut, Lebanon. Medical Learning Skills Academy, Beirut, Lebanon.
                Competing Interests

                No competing interests 

              • Naseeb Danaf Lebanese University, Faculty of Medical Sciences, Beirut, Lebanon. Lebanese University, Faculty of Science, Beirut, Lebanon. Medical Learning Skills Academy, Beirut, Lebanon.
                  Competing Interests

                  No competing interests 

                • Lea El Ghawi Medical Learning Skills Academy, Beirut, Lebanon. Saint Joseph’s University, Faculty of Medical Sciences, Beirut, Lebanon.
                    Competing Interests

                    No competing interests 

                  • Layal Msheik Lebanese University, Faculty of Medical Sciences, Beirut, Lebanon. Lebanese University, Faculty of Science, Beirut, Lebanon. Medical Learning Skills Academy, Beirut, Lebanon. https://orcid.org/0000-0001-9657-6968
                      Competing Interests

                      No competing interests 

                    • Hiba Hamdar Medical Learning Skills Academy, Beirut, Lebanon. https://orcid.org/0000-0002-4488-7323 (unauthenticated)
                        Competing Interests

                        No competing interests 

                         

                      DOI:

                      https://doi.org/10.71079/ASIDE.IM.06022554

                      Abstract

                      This review explores the potential therapeutic benefits of probiotics in the treatment of burn injuries, with the aim of addressing the limitations of traditional therapeutic approaches. It offers a comprehensive analysis of burn pathophysiology, including a wide range of burn forms and the biological reactions they induce, such as pain, inflammation, fluid imbalance, and metabolic alterations. It also specifically explains the mechanisms by which probiotics contribute to the improved healing of wounds and modified gut microbiota, as they are particularly effective in these two directions. This study looks at the ways probiotic treatment can facilitate the regeneration of the skin, which is crucial for accelerating burn recovery . Furthermore, it examines the barriers and limits of probiotic therapy, such as strain regularity and safety issues in immunocompromised patients, while emphasizing the interdependent benefits of probiotics and nutrition in promoting burn healing. This review highlights the advantages of probiotics in burn management and their potential as an adjuvant therapy for enhancing treatment results and patient well-being in the burn care context.

                      Keywords:

                      Probiotics, Burns, Inflammation, microbiota

                      References

                      1. Sanchez B, Delgado S, Blanco-Miguez A, Lourenco A, Gueimonde M, Margolles A. Probiotics, gut microbiota, and their influence on host health and disease. Mol Nutr Food Res. 2017: [PMID: 27500859, https://doi.org/10.1002/mnfr.201600240] DOI: https://doi.org/10.1002/mnfr.201600240

                      2. Iddins CJ, DiCarlo AL, Ervin MD, Herrera-Reyes E, Goans RE. Cutaneous and local radiation injuries. J Radiol Prot. 2022: [PMID: 34488201, https://doi.org/10.1088/1361-6498/ac241a] DOI: https://doi.org/10.1088/1361-6498/ac241a

                      3. Delano MJ, Ward PA. The immune system's role in sepsis progression, resolution, and long-term outcome. Immunol Rev. 2016: 330 [PMID: 27782333, https://doi.org/10.1111/imr.12499] DOI: https://doi.org/10.1111/imr.12499

                      4. Corcione S, Lupia T, De Rosa FG, Host, Microbiota Interaction Study Group of the European Society of Clinical M, Infectious D. Microbiome in the setting of burn patients: implications for infections and clinical outcomes. Burns Trauma. 2020: tkaa033 [PMID: 32821744, https://doi.org/10.1093/burnst/tkaa033] DOI: https://doi.org/10.1093/burnst/tkaa033

                      5. Weinand C. Associated bacterial and fungal infections in burn wounds: Common factors, distribution in etiology, age groups, bacterial and fungal strands – Evaluation of a single burn center experience of 20 years. Burns Open. 2024: https://doi.org/10.1016/j.burnso.2024.100363] DOI: https://doi.org/10.1016/j.burnso.2024.100363

                      6. Kaistha SD, Deshpande N. Traditional Probiotics, Next-Generation Probiotics, and Engineered Live Biotherapeutic Products in Chronic Wound Healing. Springer. 247 https://doi.org/10.1007/978-981-16-2677-7_8] DOI: https://doi.org/10.1007/978-981-16-2677-7_8

                      7. El-Ghazely MH, Mahmoud WH, Atia MA, Eldip EM. Effect of probiotic administration in the therapy of pediatric thermal burn. Ann Burns Fire Disasters. 2016: 268 [PMID: 28289360,

                      8. Notay M, Saric-Bosanac S, Vaughn AR, Dhaliwal S, Trivedi M, Reiter PN, Rybak I, Li CC, Weiss LB, Ambrogio L, Burney W, Sivamani RK. The use of topical Nitrosomonas eutropha for cosmetic improvement of facial wrinkles. J Cosmet Dermatol. 2020: 689 [PMID: 31257694, https://doi.org/10.1111/jocd.13060] DOI: https://doi.org/10.1111/jocd.13060

                      9. Jung YO, Jeong H, Cho Y, Lee EO, Jang HW, Kim J, Nam K, Lim KM. Lysates of a Probiotic, Lactobacillus rhamnosus, Can Improve Skin Barrier Function in a Reconstructed Human Epidermis Model. Int J Mol Sci. 2019: [PMID: 31480681, https://doi.org/10.3390/ijms20174289] DOI: https://doi.org/10.3390/ijms20174289

                      10. Im AR, Lee B, Kang DJ, Chae S. Protective effects of tyndallized Lactobacillus acidophilus IDCC 3302 against UVB‑induced photodamage to epidermal keratinocytes cells. Int J Mol Med. 2019: 2499 [PMID: 31017257, https://doi.org/10.3892/ijmm.2019.4161] DOI: https://doi.org/10.3892/ijmm.2019.4161

                      11. Knackstedt R, Knackstedt T, Gatherwright J. The role of topical probiotics on wound healing: A review of animal and human studies. Int Wound J. 2020: 1687 [PMID: 32869480, https://doi.org/10.1111/iwj.13451] DOI: https://doi.org/10.1111/iwj.13451

                      12. Oryan A, Jalili M, Kamali A, Nikahval B. The concurrent use of probiotic microorganism and collagen hydrogel/scaffold enhances burn wound healing: An in vivo evaluation. Burns. 2018: 1775 [PMID: 30078473, https://doi.org/10.1016/j.burns.2018.05.016] DOI: https://doi.org/10.1016/j.burns.2018.05.016

                      13. Capurso L. Thirty Years of Lactobacillus rhamnosus GG: A Review. J Clin Gastroenterol. 2019: S1 [PMID: 30741841, https://doi.org/10.1097/MCG.0000000000001170] DOI: https://doi.org/10.1097/MCG.0000000000001170

                      14. Rocchetti MT, Russo P, Capozzi V, Drider D, Spano G, Fiocco D. Bioprospecting Antimicrobials from Lactiplantibacillus plantarum: Key Factors Underlying Its Probiotic Action. Int J Mol Sci. 2021: [PMID: 34769500, https://doi.org/10.3390/ijms222112076] DOI: https://doi.org/10.3390/ijms222112076

                      15. Gilliam CH, Brazelton de Cardenas J, Carias D, Maron Alfaro G, Hayden RT, Hakim H. Lactobacillus bloodstream infections genetically related to probiotic use in pediatric hematopoietic cell transplant patients. Infect Control Hosp Epidemiol. 2023: 484 [PMID: 35225182, https://doi.org/10.1017/ice.2021.515] DOI: https://doi.org/10.1017/ice.2021.515

                      16. Eze UJ, Lal A, Elkoush MI, Halytska M, Atif S. Recurrent Lactobacillus Rhamnoses Bacteremia and Complications in an Immunocompromised Patient With History of Probiotic Use: A Case Report. Cureus. 2024: e54879 [PMID: 38550408, https://doi.org/10.7759/cureus.54879] DOI: https://doi.org/10.7759/cureus.54879

                      17. Haranahalli Nataraj B, Behare PV, Yadav H, Srivastava AK. Emerging pre-clinical safety assessments for potential probiotic strains: a review. Crit Rev Food Sci Nutr. 2024: 8155 [PMID: 37039078, https://doi.org/10.1080/10408398.2023.2197066] DOI: https://doi.org/10.1080/10408398.2023.2197066

                      18. Soleymanzadeh Moghadam S, Momeni M, Mazar Atabaki S, Mousavi Shabestari T, Boustanshenas M, Afshar M, Roham M. Topical Treatment of Second-Degree Burn Wounds with Lactobacillus plantarum Supernatant: Phase I Trial. Iran J Pathol. 2022: 460 [PMID: 36532643, https://doi.org/10.30699/ijp.2022.551202.2863] DOI: https://doi.org/10.30699/ijp.2022.551202.2863

                      19. Almadani YH, Vorstenbosch J, Davison PG, Murphy AM. Wound Healing: A Comprehensive Review. Semin Plast Surg. 2021: 141 [PMID: 34526860, https://doi.org/10.1055/s-0041-1731791] DOI: https://doi.org/10.1055/s-0041-1731791

                      20. Castana O, Anagiotos G, Rempelos G, Adalopoulou A, Kokkinakis C, Giannakidou M, Diplas DB, Alexakis D. Pain response and pain control in burn patients. Ann Burns Fire Disasters. 2009: 88 [PMID: 21991161,

                      21. Clark A, Imran J, Madni T, Wolf SE. Nutrition and metabolism in burn patients. Burns Trauma. 2017: 11 [PMID: 28428966, https://doi.org/10.1186/s41038-017-0076-x] DOI: https://doi.org/10.1186/s41038-017-0076-x

                      22. Markiewicz-Gospodarek A, Koziol M, Tobiasz M, Baj J, Radzikowska-Buchner E, Przekora A. Burn Wound Healing: Clinical Complications, Medical Care, Treatment, and Dressing Types: The Current State of Knowledge for Clinical Practice. Int J Environ Res Public Health. 2022: [PMID: 35162360, https://doi.org/10.3390/ijerph19031338] DOI: https://doi.org/10.3390/ijerph19031338

                      23. Luck ME, Herrnreiter CJ, Choudhry MA. Gut Microbial Changes and their Contribution to Post-Burn Pathology. Shock. 2021: 329 [PMID: 33481548, https://doi.org/10.1097/SHK.0000000000001736] DOI: https://doi.org/10.1097/SHK.0000000000001736

                      24. Shimizu K, Ogura H, Asahara T, Nomoto K, Matsushima A, Hayakawa K, Ikegawa H, Tasaki O, Kuwagata Y, Shimazu T. Gut microbiota and environment in patients with major burns - a preliminary report. Burns. 2015: e28 [PMID: 25465986, https://doi.org/10.1016/j.burns.2014.10.019] DOI: https://doi.org/10.1016/j.burns.2014.10.019

                      25. McMahan RH, Boe DM, Walrath TM, Idrovo JP, Kovacs EJ. Aging, Cutaneous Burn Injury and Multi-Organ Complications: The Role of the Gut. Adv Geriatr Med Res. 2022: [PMID: 35913894, https://doi.org/10.20900/agmr20220004] DOI: https://doi.org/10.20900/agmr20220004

                      26. Pan YY, Fan YF, Li JL, Cui SY, Huang N, Jin GY, Chen C, Zhang C. [Analysis of the dynamic changes in gut microbiota in patients with extremely severe burns by 16S ribosomal RNA high-throughput sequencing technology]. Zhonghua Shao Shang Za Zhi. 2020: 1159 [PMID: 33379852, https://doi.org/10.3760/cma.j.cn501120-20200518-00271]

                      27. Lima KM, Davis RR, Liu SY, Greenhalgh DG, Tran NK. Longitudinal profiling of the burn patient cutaneous and gastrointestinal microbiota: a pilot study. Sci Rep. 2021: 10667 [PMID: 34021204, https://doi.org/10.1038/s41598-021-89822-z] DOI: https://doi.org/10.21203/rs.3.rs-240723/v1

                      28. Jandhyala SM, Talukdar R, Subramanyam C, Vuyyuru H, Sasikala M, Nageshwar Reddy D. Role of the normal gut microbiota. World J Gastroenterol. 2015: 8787 [PMID: 26269668, https://doi.org/10.3748/wjg.v21.i29.8787] DOI: https://doi.org/10.3748/wjg.v21.i29.8787

                      29. Rooks MG, Garrett WS. Gut microbiota, metabolites and host immunity. Nat Rev Immunol. 2016: 341 [PMID: 27231050, https://doi.org/10.1038/nri.2016.42] DOI: https://doi.org/10.1038/nri.2016.42

                      30. Jeschke MG, van Baar ME, Choudhry MA, Chung KK, Gibran NS, Logsetty S. Burn injury. Nat Rev Dis Primers. 2020: 11 [PMID: 32054846, https://doi.org/10.1038/s41572-020-0145-5] DOI: https://doi.org/10.1038/s41572-020-0145-5

                      31. Earley ZM, Akhtar S, Green SJ, Naqib A, Khan O, Cannon AR, Hammer AM, Morris NL, Li X, Eberhardt JM, Gamelli RL, Kennedy RH, Choudhry MA. Burn Injury Alters the Intestinal Microbiome and Increases Gut Permeability and Bacterial Translocation. PLoS One. 2015: e0129996 [PMID: 26154283, https://doi.org/10.1371/journal.pone.0129996] DOI: https://doi.org/10.1371/journal.pone.0129996

                      32. Wrba L, Palmer A, Braun CK, Huber-Lang M. Evaluation of gut-blood barrier dysfunction in various models of trauma, hemorrhagic shock, and burn injury. J Trauma Acute Care Surg. 2017: 944 [PMID: 28700414, https://doi.org/10.1097/TA.0000000000001654] DOI: https://doi.org/10.1097/TA.0000000000001654

                      33. Odamaki T, Kato K, Sugahara H, Hashikura N, Takahashi S, Xiao JZ, Abe F, Osawa R. Age-related changes in gut microbiota composition from newborn to centenarian: a cross-sectional study. BMC Microbiol. 2016: 90 [PMID: 27220822, https://doi.org/10.1186/s12866-016-0708-5] DOI: https://doi.org/10.1186/s12866-016-0708-5

                      34. Zhang CX, Wang HY, Chen TX. Interactions between Intestinal Microflora/Probiotics and the Immune System. Biomed Res Int. 2019: 6764919 [PMID: 31828119, https://doi.org/10.1155/2019/6764919] DOI: https://doi.org/10.1155/2019/6764919

                      35. Wang X, Zhang P, Zhang X. Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity. Molecules. 2021: [PMID: 34641619, https://doi.org/10.3390/molecules26196076] DOI: https://doi.org/10.3390/molecules26196076

                      36. Stavrou G, Kotzampassi K. Gut microbiome, surgical complications and probiotics. Ann Gastroenterol. 2017: 45 [PMID: 28042237, https://doi.org/10.20524/aog.2016.0086] DOI: https://doi.org/10.20524/aog.2016.0086

                      37. Maldonado Galdeano C, Cazorla SI, Lemme Dumit JM, Velez E, Perdigon G. Beneficial Effects of Probiotic Consumption on the Immune System. Ann Nutr Metab. 2019: 115 [PMID: 30673668, https://doi.org/10.1159/000496426] DOI: https://doi.org/10.1159/000496426

                      38. La Fata G, Weber P, Mohajeri MH. Probiotics and the Gut Immune System: Indirect Regulation. Probiotics Antimicrob Proteins. 2018: 11 [PMID: 28861741, https://doi.org/10.1007/s12602-017-9322-6] DOI: https://doi.org/10.1007/s12602-017-9322-6

                      39. Liu Q, Yu Z, Tian F, Zhao J, Zhang H, Zhai Q, Chen W. Surface components and metabolites of probiotics for regulation of intestinal epithelial barrier. Microb Cell Fact. 2020: 23 [PMID: 32024520, https://doi.org/10.1186/s12934-020-1289-4] DOI: https://doi.org/10.1186/s12934-020-1289-4

                      40. Rocha-Ramirez LM, Perez-Solano RA, Castanon-Alonso SL, Moreno Guerrero SS, Ramirez Pacheco A, Garcia Garibay M, Eslava C. Probiotic Lactobacillus Strains Stimulate the Inflammatory Response and Activate Human Macrophages. J Immunol Res. 2017: 4607491 [PMID: 28758133, https://doi.org/10.1155/2017/4607491] DOI: https://doi.org/10.1155/2017/4607491

                      41. Grice EA, Segre JA. The skin microbiome. Nat Rev Microbiol. 2011: 244 [PMID: 21407241, https://doi.org/10.1038/nrmicro2537] DOI: https://doi.org/10.1038/nrmicro2537

                      42. Stecker RA, Moon JM, Russo TJ, Ratliff KM, Mumford PW, Jager R, Purpura M, Kerksick CM. Bacillus coagulans GBI-30, 6086 improves amino acid absorption from milk protein. Nutr Metab (Lond). 2020: 93 [PMID: 33110439, https://doi.org/10.1186/s12986-020-00515-2] DOI: https://doi.org/10.1186/s12986-020-00515-2

                      43. Canchy L, Kerob D, Demessant A, Amici JM. Wound healing and microbiome, an unexpected relationship. J Eur Acad Dermatol Venereol. 2023: 7 [PMID: 36635613, https://doi.org/10.1111/jdv.18854] DOI: https://doi.org/10.1111/jdv.18854

                      44. Bates M. The Role of the Skin Microbiome in Health and Disease. IEEE Pulse. 2022: 8 [PMID: 36044472, https://doi.org/10.1109/MPULS.2022.3191384] DOI: https://doi.org/10.1109/MPULS.2022.3191384

                      45. Mahmud MR, Akter S, Tamanna SK, Mazumder L, Esti IZ, Banerjee S, Akter S, Hasan MR, Acharjee M, Hossain MS, Pirttila AM. Impact of gut microbiome on skin health: gut-skin axis observed through the lenses of therapeutics and skin diseases. Gut Microbes. 2022: 2096995 [PMID: 35866234, https://doi.org/10.1080/19490976.2022.2096995] DOI: https://doi.org/10.1080/19490976.2022.2096995

                      46. Habeebuddin M, Karnati RK, Shiroorkar PN, Nagaraja S, Asdaq SMB, Khalid Anwer M, Fattepur S. Topical Probiotics: More Than a Skin Deep. Pharmaceutics. 2022: [PMID: 35335933, https://doi.org/10.3390/pharmaceutics14030557] DOI: https://doi.org/10.3390/pharmaceutics14030557

                      47. Sharma G, Khanna G, Sharma P, Deol PK, Kaur IP. Mechanistic Role of Probiotics in Improving Skin Health. In: Beri K, Deol PK, Sandhu SK, editors. Probiotic Research in Therapeutics2022. p. 27-47. DOI: https://doi.org/10.1007/978-981-16-5628-6_2

                      48. Lukic J, Chen V, Strahinic I, Begovic J, Lev-Tov H, Davis SC, Tomic-Canic M, Pastar I. Probiotics or pro-healers: the role of beneficial bacteria in tissue repair. Wound Repair Regen. 2017: 912 [PMID: 29315980, https://doi.org/10.1111/wrr.12607] DOI: https://doi.org/10.1111/wrr.12607

                      49. Horseman TS, Frank AM, Shupp JW, Burmeister DM. Meta-Analysis of Publicly Available Clinical and Preclinical Microbiome Data From Studies of Burn Injury. J Burn Care Res. 2023: 1041 [PMID: 37352011, https://doi.org/10.1093/jbcr/irad098] DOI: https://doi.org/10.1093/jbcr/irad098

                      50. Maslova E, Osman S, McCarthy RR. Using the Galleria mellonella burn wound and infection model to identify and characterize potential wound probiotics. Microbiology (Reading). 2023: [PMID: 37350463, https://doi.org/10.1099/mic.0.001350] DOI: https://doi.org/10.1099/mic.0.001350

                      51. Mayes T, Gottschlich MM, James LE, Allgeier C, Weitz J, Kagan RJ. Clinical safety and efficacy of probiotic administration following burn injury. J Burn Care Res. 2015: 92 [PMID: 25559730, https://doi.org/10.1097/BCR.0000000000000139] DOI: https://doi.org/10.1097/BCR.0000000000000139

                      52. Shrivastava S, Bhatu N. A Study on the Usage of Probiotics as a Safer Antipyretic. Journal of Cellular Signaling. 2023: 73 https://doi.org/10.33696/Signaling.4.093] DOI: https://doi.org/10.33696/Signaling.4.093

                      53. Bremmer F, Strobel P. [Mediastinal germ cell tumors]. Pathologe. 2016: 441 [PMID: 27491549, https://doi.org/10.1007/s00292-016-0196-2] DOI: https://doi.org/10.1007/s00292-016-0196-2

                      54. Wang X, Yang Y, Huycke MM. Risks associated with enterococci as probiotics. Food Res Int. 2020: 108788 [PMID: 32036912, https://doi.org/10.1016/j.foodres.2019.108788] DOI: https://doi.org/10.1016/j.foodres.2019.108788

                      55. Golchin A, Ranjbarvan P, Parviz S, Shokati A, Naderi R, Rasmi Y, Kiani S, Moradi F, Heidari F, Saltanatpour Z, Alizadeh A. The role of probiotics in tissue engineering and regenerative medicine. Regen Med. 2023: 635 [PMID: 37492007, https://doi.org/10.2217/rme-2022-0209] DOI: https://doi.org/10.2217/rme-2022-0209

                      56. Han Y, Ren QL. Does probiotics work for bacterial vaginosis and vulvovaginal candidiasis. Curr Opin Pharmacol. 2021: 83 [PMID: 34649216, https://doi.org/10.1016/j.coph.2021.09.004] DOI: https://doi.org/10.1016/j.coph.2021.09.004

                      57. Neveling DP, Dicks LMT. Probiotics: an Antibiotic Replacement Strategy for Healthy Broilers and Productive Rearing. Probiotics Antimicrob Proteins. 2021: 1 [PMID: 32556932, https://doi.org/10.1007/s12602-020-09640-z] DOI: https://doi.org/10.1007/s12602-020-09640-z

                      58. Peral MC, Martinez MA, Valdez JC. Bacteriotherapy with Lactobacillus plantarum in burns. Int Wound J. 2009: 73 [PMID: 19291120, https://doi.org/10.1111/j.1742-481X.2008.00577.x] DOI: https://doi.org/10.1111/j.1742-481X.2008.00577.x

                      59. Thomson CH, Hassan I, Dunn K. Yakult: a role in combating multi-drug resistant Pseudomonas aeruginosa? J Wound Care. 2012: 566 [PMID: 23413495, https://doi.org/10.12968/jowc.2012.21.11.566] DOI: https://doi.org/10.12968/jowc.2012.21.11.566

                      Data Availability Statement

                      This review article does not contain any new primary data. All information discussed is derived from previously published sources and publicly available databases, as cited in the manuscript.

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                      Copyright (c) 2025 Kholoud Al Jebawi, Jobran Toami, Adel Ayash, Razan Salha, Mira Al Shoufy, Jamil Nasrallah , Naseeb Danaf, Lea El Ghawi, Layal Msheik, Hiba Hamdar

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                      Mechanism of action of probiotics in wound and burn management.

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                      Published

                      2025-06-02

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                      Vol. 1 No. 4 (2025): Volume 1, Issue 4 (2025)

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                      Review Article

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                      How to Cite

                      1.
                      Al Jebawi K, Toami J, Ayash A, et al. Probiotics: A Promising Ally in Burn Treatment. ASIDE Int Med. 2025;1(4):10-17. doi:10.71079/ASIDE.IM.06022554

                      Article history

                      Received
                      25 Mar 2025
                      Received in revised form
                      9 May 2025
                      Accepted
                      25 May 2025
                      Published
                      2 Jun 2025