ASIDE Gastroenterology Vol. 2, No. 2 (May 1, 2026) presents a focused collection of clinically relevant scholarship spanning biliary disease, hepatic abscess, metabolic liver disease, and diagnostic challenges in chronic diarrhea. The issue features an original meta-analysis comparing one-stage versus two-stage ERCP strategies in gallstone disease, highlighting outcomes related to common bile duct clearance, complications, and hospital stay. It also includes a scoping review of fish-bone migration to the liver as an uncommon cause of hepatic abscess, emphasizing diagnostic vigilance and source control. Two narrative reviews explore the expanding clinical implications of metabolic dysfunction-associated steatotic liver disease, including its cardiovascular, oncological, and liver-heart axis dimensions. Completing the issue is a two-case series demonstrating the value of random colonic biopsy in patients with chronic diarrhea and normal colonoscopy, including biopsy-detected microscopic colitis and nonspecific chronic inflammatory change. Collectively, this issue reinforces ASIDE Gastroenterology’s commitment to practice-focused research, careful diagnostic reasoning, and clinically meaningful advances in gastroenterology and hepatology.